牡丹皮化学成分研究
牡丹皮化学成分研究
【摘要】目的 研究牡丹皮的化学成分。方法 利用反相色谱的方法分离纯化, 根据化合物的化学性质与光谱数据鉴定结构。结果 牡丹皮的70%乙醇提取物中分得8个化合物, 确定其结构分别为mudanpioside-E (1), oxypaeoniflorin (2),mudanpioside A (3), 尿嘧啶核甙 (4),胸腺嘧啶脱氧核苷 (5),丹皮酚(6), 色氨酸
(7),没食子酸 (8)。结论 化合物4和5为首次从该植物中分得。
【关键词】牡丹皮;水溶性成分
Studies on Chemical Constituents in the Root cortex of Paeonia Suffruticosa YU Zhao-Hai.(Department of Pharmacy, People’s Hospital of Jiaonan, Jiaonan 266400, Shandong, China)
【Abstract 】Objective To study the chemical constituents from Paeonia suffruticosa.Methods The constituents were isolated by reverse-phased materials, and their structures were characterized by chemical property and spectral analysis.Results Eight compounds were isolated from the 70% ethanol extract of the leaves of Paeonia suffruticosa. Their structures were elucidated as mudanpioside-E (1), oxypaeoniflorin
(2), mudanpioside A (3), uridine (4), thymidine (5), paeonol (6) tryptophan (7) and gallic acid (8), respectively. Conclusion Compounds 4 and 5 are isolated from this plant for the first time.
【Key Words】 Paeonia suffruticosa; chemical constituents
牡丹皮,又名牡丹根皮,丹皮,丹根,为芍药科植物牡丹(Paeonia suffruticosa Andr.) 的根皮,全国各地均有栽培,来源广,为常用中药。它味苦、辛,性微寒;归心、肝、肾经;具有清热凉血,活血散淤之功效。主治温热病热入血分,发斑,热病后期热伏阴分发热,阴虚骨蒸潮热和跌扑伤痛等。现代临床用于治疗高血压,过敏性鼻炎,湿疹类皮肤病,皮肤瘙痒症,并可以治疗各种手术后疼痛,以及急性腰腿痛,风湿痛,胃及十二指肠溃疡痛等[1]。
为了寻找有效成分,并为中药质量标准化提供依据,作者对牡丹皮的水溶性部位进行了化学成分的研究,从中分离鉴定了8个化合物:经过化学分析和1H-NMR 、13C-NMR 等光谱解析,并与文献报道数据对照,分别确定为: mudanpioside-E (1), oxypaeoniflorin (2),mudanpioside A (3),尿嘧啶核苷(4),胸腺嘧啶脱氧核苷(5),丹皮酚(6),色氨酸(7)和没食子酸(8)。化合物4和5为首次从该植物中分得。