术后高热病人氧化应激状态观察
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术后高热病人氧化应激状态观察
作者：施伟民 庄志祥
来源：《延边医学》2014年第16期
摘要：目的：研究外科术后高热与氧化应激的关联性，为外科术后发热治疗寻找新的思路。方法：研究2012 -08?2013-09本院外科34例住院病人，术后检测血清丙二醛浓度变化，比较术后高热组和非高热组病人在术后第2d ，4d 的MDA 浓度差异，同时记录出器官功能障碍的数目，分析MDA 浓度与器官功能障碍的关系。结果： 术后高热组病人MDA 浓度高于非高热组（11.79± 1.92)μmol/Lvs(7.21 ±1.79)μmol/L,P
关键词：手术；发热；氧化应激
Clinical Analysis Oxidative Stress in Fever - patients after Operation SHI Weimin/SHI Wei – min ，ZHUANG Zhi -xiang// Department of General surgency, The AffiliatedSuzhou TCM Hospital of Nanjing Chinese Medicine Uiversity,Suzhou 215003, China
Abstract：Objective :Toinvestigate the oxidative stress in postoperative fever -
patientsandexploreanew strategy for it. Methods :34 postoperative patients divided into fever - group and non - fever - group were involved. Serum malondialdehyde (MDA); data of were mesured，at the second and :the fourth day after operation. MDA level were comparedbetween，different groups. At the same lime organ function was observed and the numbers of dysfunction organ were recorded. The relationship be- tween MDA level and organ injury vas analyzed. Results:MDA was significantly higher in fever - patients than non - fever - pa?tients ( 11 .79 ± 1.92) μmol/Lvs (7.21 ± 1.79) μmol/L, P
外科术后高热机制尚未明确，氧化应激和外科感染是其重要因素。术后高热可发展为多器官功能障碍综合征 (Multiple organ dysfunction syndrome MODS)。目前 MODS 的发病机理仍未明确，手术创伤、感染等氧化应激可能是其中一个致病因素[1]我们通过对术后病人检测丙二醛（mnalondi- aldenhyde, MDA)浓度，深入研究术后发热病人体内氧化应 激与器官功能障碍的关系。
1 资料与方法
1.1 一般资料2012 - 08 ~2013-09 本院外科危重病人手术后进入重症监护病房（S1CU), 共34例，其中男20例, 女 14例; 病种包括严重创伤、复合伤（均重大手术后）及术后立即出现严重感染者（如胸、腹腔感染等）。根据有无术后高热将病例分为两组：术后高热组18例，术后发热≧38.5℃，并维持在2d 以上; 术后非高热组16例。