线粒体膜电位和精子活力
线粒体膜电位和精子活力
精子线粒体决定了生育力吗？
背景
线粒体膜电位 (MMP) 是反映线粒体能量状态的指标。研究表明，降低人体 MMP 值会导致人精子活力和生育能力下降。 这项研究用 MMP 来评估精子线粒体的完整性，以确定 MMP 的基本情况是否与精子活力的不同程度有关。
意大利罗马大学精液学实验室收集了 213 名年龄为 25-38 岁男性的精液样本；进行了精液检查、精子活力检测和 MMP 流式细胞分析。
根据活力情况将样本分为两组：A 组包含 185 例具有线性活力的样本，根据活力的递增将这些样品分为 13 个层级；B 组包含 28 例具有非线性活力的样本，分为 5 个层级。
（A 组 FL2 平均值：A 组和 B 组的 MMP 测量值没有显著的差异46.2；
B 组：48.3）。
A 组中， 随着活动精子百分比的增加，MMP 值升高。
同样，在 B 组中可以观察到，MMP 与递增的非线性活力呈正相关关系。 这项研究首次明确了与活动精子的不同等级相关的 MMP 情况，并且首次评估了具有非线性活力的精子的 MMP。
结论
作者总结道，“我们的数据揭示总活力与 MMP 之间存在正相关关系，表明精子活力可能取决于线粒体的功能完整性。”
Paoli D, Gallo M, Rizzo F, et al. Mitochondrial membrane potential profile and its correlation with increasing sperm motility. Fertil Steril. 2011;95:2315-9. Purchase full-text article at PubMed
Purchase full-text article at PubMed
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