Eur Heart J:​你还会加班吗?每周工作超55小时房颤风险增加

2017年7月13日国际顶尖期刊Eur Heart J(IF19.65)刊发了来自伦敦大学/赫尔辛基大学的文章：Long working hours as a risk factor for atrial fibrillation: a multi-cohort study。研究指出，工作时间过长可能是房颤的危险因素之一。

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以下是文章首页：

Abstract

Aims

Studies suggest that people who work long hours are at increased risk of stroke, but the association of long working hours with atrial fibrillation, the most common cardiac arrhythmia and a risk factor for stroke, is unknown. We examined the risk of atrial fibrillation in individuals working long hours (≥55 per week) and those working standard 35–40 h/week.

Methods and results

In this prospective multi-cohort study from the Individual-Participant-Data Meta-analysis in Working Populations (IPD-Work) Consortium, the study population was 85 494 working men and women (mean age 43.4 years) with no recorded atrial fibrillation. Working hours were assessed at study baseline (1991–2004). Mean follow-up for incident atrial fibrillation was 10 years and cases were defined using data on electrocardiograms, hospital records, drug reimbursement registers, and death certificates. We identified 1061 new cases of atrial fibrillation (10-year cumulative incidence 12.4 per 1000). After adjustment for age, sex and socioeconomic status, individuals working long hours had a 1.4-fold increased risk of atrial fibrillation compared with those working standard hours (hazard ratio = 1.42, 95% CI = 1.13–1.80, P = 0.003). There was no significant heterogeneity between the cohort-specific effect estimates (I2 = 0%, P = 0.66) and the finding remained after excluding participants with coronary heart disease or stroke at baseline or during the follow-up (N= 2006, hazard ratio = 1.36, 95% CI = 1.05–1.76, P = 0.0180). Adjustment for potential confounding factors, such as obesity, risky alcohol use and high blood pressure, had little impact on this association.

Conclusion

Individuals who worked long hours were more likely to develop atrial fibrillation than those working standard hours.

摘要

目的

研究表明长时间工作的人患中风的风险增加，但长时间工作与房颤的关系(房颤是最常见的心律失常，也是中风的危险因素),尚不明确。我们研究了个人工作时长，每周大于55小时和标准工作时长35–40小时/周，房颤发生的风险。

方法和结果

在这项前瞻性的多队列研究中发现，房颤1061例（10年累积发病率12.4／1000）。在调整年龄、性别和社会经济地位后，与正常工作时长相比，工作时长大于55小时的房颤的风险增加了1.4倍（危险比= 1.42，95% CI = 1.13–1.80，P = 0.003）。调整潜在的混杂因素，如肥胖、饮酒和高血压等，对这种关系没有什么影响。

结论

长时间工作的人比正常工作时间患房颤的可能性更大。

那么，每周工作超55小时房颤风险就一定会增加吗？

这项研究中的受试者来自于欧洲，入选时无房颤，根据每周工作时间，分为：小于35h、35~40h、41~48h、49~54h、≥55小时。当然，对健康的年轻人来说，房颤绝对风险相对来讲，并不大。

另外，本文对应的述评中，专家认为研究没有考虑工作类型和不规律工作时间等问题。

原始出处：

Kivimk M, Nyberg ST, Batty GD, et al. Long working hours as a risk factor for atrial fibrillation: a multi-cohort study. Eur Heart J. DOI: https://doi.org/10.1093/eurheartj/ehx324

Published: 13 July 2017

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