底物.抑制剂.诱导剂列表
How to Use This Table
This table is an abridged guide to P-450 drug interactions which can be greatly exacerbated by common
genetic variations (present in half of the population). To appreciate the full benefits of this information, go to www.GeneMedRx.com for a free 30-day trial version of GeneMedRx. This genetics enabled drug interaction software predicts response to medication combinations with optional input of genetic variations.
P450 DRUG-INTERACTIONS TABLE
Substrates (main pathway for metabolism) italics=minor pathway bold=only pathway NAT2 1A2 2D6 2C9 2C19 3A4,5,7
caffeine caspofungin dapsone hydralazine isoniazid nitrazepam procainamide retigabine sulfadiazine zonisamide
Sulfonamides: sulfapyridine sulfamethazine sulfadiazine sulfasalazine carcinogenic aromatic and heterocyclic amines benzidine beta-naphthylamine
Analgesics:
acetaminophen
Antidepressants : amitriptyline brofaramine bupropion clomipramine doxepin fluvoxamine imipramine maprotline mirtazapine
Anti-epileptics: carbamazepine
Antipsychotics: chlorpromazine clozapine fluphenazine haloperidol olanzapine perphenazine pimozide thioridazine
Cardiovascular : brofaramine flecainide lidocaine mexiletine propafenone propranolol verapamil
HIV Antivirals: ritonavir
NSAIDs: Naproxen
Miscellaneous : caffeine
cyclobenzaprine clopidogrel flutamide frovatriptan melatonin
metoclopramide ondansetron proguanil quinine rifabutin riluzole ranitidine ropivacaine tacrine teniposide theophylline warfarin zileuton
zolmitriptan zolpidem
Analgesics: acetaminophen hydrocodone methadone oxycodone tramadol
Antidepressants : amitriptyline brofaramine bupropion
clomipramine desipramine doxepin fluoxetine fluvoxamine imipramine maprotline mirtazapine nortriptyline paroxetine trazodone trimipramine venlafaxine
Antihistamines: chlorpheniramine
Antipsychotics: chlorpromazine fluphenazine haloperidol mesoridazine olanzapine perphenazine risperidone thioridazine
Cardiovascular : alprenolol carvedilol flecainide metoprolol mexiletine propafenone propranolol verapamil
Anti- ADHD amphetamines atomoxetine
HIV Antiviralsamprenavir delavirdine ritonavir
HMG CoA Reductase Inhibitors: simvastatin
Miscellaneous: amphetamine buspirone chloroquine
cyclobenzaprine dextromethorphan doxorubicin
metoclopramide ondansetron ranitidine tacrine tamoxifen timolol
Analgesics: methadone
Angiotensin II Blockers: irbesartan losartan
Antibiotics: rifampin
Antidepressants : amitriptyline bupropion fluoxetine sertraline trimipramine
Anti-epileptics: phenytoin
Cardiovascular : carvedilol quinidine diltiazem
HIV Antivirals: amprenavir
Hormone: progesterone
HMG CoA Reductase Inhibitors: fluvastatin lovastatin
NSAIDs: celecoxib diclofenac ibuprofen indomethacin mefenamic acid meloxicam naproxen piroxicam suprofen Oral
Hypoglycemics: glimepiride glipizide glyburide tolbutamide
Proton Pump Inhibitors: omeprazole
Miscellaneous: cyclophosphamide dextromethorphan dapsone
esomeprazole halofantrine phenobarbital mephobarbital sildenafil
sulfamethoxazole torsemide valproic acid warfarin zafirlukast zileuton zolpidem
Analgesics: methadone
Antidepressants: amitriptyline clomipramine citalopram doxepin fluoxetine imipramine maclobemide sertraline trimipramine
Anti-epileptics: diazepam mephenytoin phenobarbitone phenytoin primidone S-mephenytoin
Antipsychotics: perphenazine thioridazine
Benzodiazepines: alprazolam diazepam
Cardiovascular : propranolol
HIV Antivirals: nelfinavir
Hormone: progesterone
NSAIDs:
Indomethacin Oral
Hypoglycemics: glyburide tolbutamide
Proton Pump Inhibitors: esomeprazole lansoprazole omeprazole pantoprazole
Miscellaneous: carisoprodol cyclophosphamide dextromethorphan dapsone
mephobarbital nilutamide phenobarbital proguanil quinine ranitidine tamoxifen
Analgesics: acetaminophen fentanyl methadone tramadol
Angiotensin II Blockers: irbesartan losartan
Antibiotics: azithromycin clarithromycin dirithromycin erythromycin rifabutin rifampin
Antidepressants: bupropion clomipramine imipramine fluoxetine fluvoxamine mirtazapine nefazodone nortriptyline sertraline trazodone venlafaxine
Anti-epileptics: carbamazepine diazepam ethosuximide felbamate tiagabine
Antihistamines: astemizole terfenadine
Antipsychotics: haloperidol perphenazine pimozide risperidone
Benzodiazepines: alprazolam diazepam triazolam
Cardiovascular : amlodipine amiodarone carvedilol diltiazem eplerenone felodipine lercanidipine lidocaine nicardipine nifedipine nisoldipine propafenone quinidine verapamil
HIV Antivirals: amprenavir delavirdine efavirenz indinavir nelfinavir ritonavir saquinavir
HMG CoA Reductase Inhibitors: atorvastatin cerivastatin lovastatin pravastatin simvastatin
Hormone: progesterone testosterone
Immune Modulators: cyclosporine tacrolimus
NSAIDs: diclofenac meloxicam Oral
Hypoglycemics:glyburide
Proton Pump Inhibitors: esomeprazole omeprazole pantoprazole
Steroid
hydrocortisone prednisone
Miscellaneous : bromocriptine buspirone caffeine chloroquine cisapride clopidogrel cocaine
cyclobenzaprine cyclophosphamide dapsone
dextromethorphan doxorubicin fluconazole flutamide halofantrine irinotecan itraconazole mifepristone ketoconazole pioglitazone proguanil quinine
rosiglitazone salmeterol sildenafil sirolimus tamoxifen taxol
teniposide ticlopidine vincristine warfarin zaleplon zolpidem zileuton
www.GeneMedRX.com
3000 First Avenue, Suite One, Seattle, WA 98121
2006 Genelex Corporation
877-431-4362
How to Use This Table
This table is an abridged guide to P-450 drug interactions which can be greatly exacerbated by common genetic variations (present in half of the population). To appreciate the full benefits of this information, go to www.GeneMedRx.com for a free 30-day trial version of GeneMedRx. This genetics enabled drug interaction software predicts response to medication combinations with optional input of genetic variations.
Inhibitors (reduces or blocks the ability of the pathway to metabolize the substrates)
3A4,5,7
NAT2 1A2 2D6 2C9 2C19
Analgesics:
acetaminophen
Antidepressants : fluvoxamine fluoxetine paroxetine sertraline
Antipsychotics: olanzapine perphenazine
Antibiotics : ciprofloxacin enoxacin grepafloxacin norfloxacin ofloxacin sparfloxacin
Cardiovascular : amiodarone lidocaine mexiletine propafenone
HIV Antivirals: delavirdine efavirenz
Miscellaneous : anastrozole caffeine cimetidine estradiol
grapefruit juice oral contraceptives tacrine ticlopidine valproic acid zileuton
Analgesics: methadone
Antidepressants : amitriptyline bupropion clomipramine desipramine fluoxetine fluvoxamine imipramine nortriptyline paroxetine sertraline venlafaxine
Antihistamines: astemizole azelastine
chlorpheniramine terfenadine
Antipsychotics: chlorpromazine clozapine fluphenazine haloperidol
chloropromazine perphenazine risperidone thioridazine
Cardiovascular : amiodarone flecainide nicardipine propafenone propranolol quinidine
HIV Antivirals: delavirdine efavirenz indinavir nelfinavir ritonavir saquinavir
HMG CoA Reductase Inhibitors: atorvastatin cerivastatin fluvastatin
NSAIDs : celecoxib diclofenac
Proton Pump Inhibitors: lansoprazole
Miscellaneous : chloroquine cimetidine cisapride cocaine doxorubicin
metoclopramide methadone tamoxifen terbinafine timolol
Angiotensin II Blockers: irbesartan losartan
Antidepressants : fluoxetine fluvoxamine paroxetine sertraline
Cardiovascular : amiodarone nicardipine
HIV Antivirals: delavirdine efavirenz ritonavir
HMG CoA Reductase Inhibitors: atorvastatin fluvastatin simvastatin Oral
Hypoglycemics:glyburide
Proton Pump Inhibitors: esomeprazole lansoprazole omeprazole pantoprazole NSAIDs: ketoprofen
Miscellaneous : anastrozole cimetidine clopidogrel fluconazole ketoconazole modafinil isoniazid
sulfamethoxazole teniposide valproic acid zafirlukast
Antidepressants : amitriptyline fluoxetine fluvoxamine imipramine paroxetine sertraline
Anti-epileptics: carbamazepine felbamate topiramate
Cardiovascular: amiodarone nicardipine nifedipine
Proton Pump Inhibitors: esomeprazole lansoprazole omeprazole HIV Antivirals: amprenavir delavirdine efavirenz ritonavir
HMG CoA Reductase Inhibitors: cerivastatin fluvastatin lovastatin simvastatin
Miscellaneous : clopidogrel cimetidine fluconazole indomethacin isoniazid modafinil nilutamide
oral contraceptives oxcarbazepine pioglitazone ticlopidine torsemide valproic acid zafirlukast
Analgesics: fentanyl
Antibiotics: ciprofloxacin clarithromycin dalfopristin enoxacin erythromycin norfloxacin telithromycin troleandomycin
Antihistamines: astemizole terfenadine
Antidepressants : fluoxetine fluvoxamine nefazodone paroxetine sertraline
Antipsychotics: pimozide
Benzodiazepines: diazepam
Cardiovascular : amiodarone amlodipine diltiazem irbesartan nicardipine nifedipine quinidine verapamil
HIV Antivirals: amprenavir delaviridine efavirenz indinavir nelfinavir ritonavir saquinavir
HMG CoA
Reductase Inhibitors: atorvastatin cerivastatin fluvastatin lovastatin simvastatin
Immune Modulators: cyclosporine tacrolimus
Oral Hypoglycemics:glyburide
Proton Pump Inhibitors: esomeprazole lansoprazole omeprazole
Miscellaneous : anastrozole bromocriptine cimetidine fluconazole grapefruit juice irinotecan isoniazid itraconazole ketoconazole mifepristone
oral contraceptives sirolimus teniposide valproic acid zafirlukast
Inducers (increases the ability of the pathway to metabolize the substrates)
3A4,5,7 NAT2 1A2 2D6 2C9 2C19
phenobarbital dexamethosone dexamethosone Analgesics: brussel sprouts phenobarbital pentobarbital methadone cabbage primidone prednisone
cauliflower esomeprazole insulin
modafinil nafcillin
phenobarbital quinine rifampin ritonavir
St. John's wort taxol
rifampin ritonavir
St. John's wort
rifampin ritonavir
St. John's wort
Antiepileptics : carbamazepine felbamate
oxcarbazepine phenobarbital phenytoin primidone topiramate
HIV Antivirals: efavirenz nevirapine
Antipsychotics: thioridazine
Miscellaneous : cyclophosphamide barbiturates
dexamethosone modafinil
phenobarbital pioglitazone prednisone rifabutin rifampin rifapentine ritonavir
St. John's wort tamoxifen
877-431-4362
www.GeneMedRX.com
3000 First Avenue, Suite One, Seattle, WA 98121
2006 Genelex Corporation