糖尿病肾病不同分期证候演变
中华中医药杂志(原中国医药学报)2012年10月第27卷第10期 CJTCMP,October 2012,Vol.27,No.10
,
using Ginseng Yizhi Decoction treating senile Alzheimers disease. Chinese Archives of TCM,2008,26(1):27-28
[10] 夏小军.谢国君诊治老年性痴呆经验.中医药临床杂志,2006,
,
XIA Xiao-jun.XIE Jun-guos experience in treating senile
,
Alzheimers disease.Clinical Journal of TCM,2006,18(2):113-114药信息,2001,18(3):1-2
ZHANG Jin,LIU Rong,DONG Jian,et al.Comments on experiences
,
of famous TCM physicians in treating senile Alzheimers disease. Information on TCM,2001,18(3):1-2
[12] 孙景波,杨志敏,符文彬,等.张学文教授论老年痴呆的形成
机制.中医脑病杂志,2006,2(2):73-74
SUN Jing-bo,YANG Zhi-min,FU Wen-bin,et al.Professor
,
ZHANG Xue-wens experience on the pathology mechanism of alzheimer disease.Senile Neuropathy Special Seminars of China Association of Chinese Medicine,2006,2(2):73-74[13] 陈骐,张宇燕,杨洁红,等.远志石菖蒲配伍抗阿尔茨海默病
模型大鼠脑自由基损伤的实验研究.世界中西医结合杂志, 2010,5(7):579-581
18(2):113-114
•
2687 •
CHEN Qi,ZHANG Yu-yan,YANG Jie-hong,et al.Experimental study of the compatibility of radix polygalae and rhizoma acori talarinowii on anti-free radical damage of the brain in rats with
,
Alzheimers disease.World Journal of Integrated Traditional and Western Medicine,2010,5(7):579-581
[14] 徐丽君,黄光英.丹参的化学成分及其药理作用研究概述.中
西医结合研究,2009,1(1):45-48
XU Li-jun,HUANG Guang-ying.The research of chemical constituents and pharmacological activities about Salvia.Research of Integrated Traditional Chinese and Western Medicine, 2009,1(1):45-48
[15] 张妍,林青,唐林科,等.复方丹参对老年痴呆模型大鼠海马和大
脑皮层ChAT_AchE活性的影响.北京中医药大学学报, 2008,3(31):192-195
ZHANG Yan,LIN Qing,TANG Lin-ke,et al.Effects of Fufangdanshen on choline acetyl transferase and acetyl cholinesterase activities of hippocampus and cerebral cortex in rats with senile dementia.Journal of Beijing University of TCM,2008,3,(31):192-195
（收稿日期：2011年7月13日）
[11] 张晋,刘荣,董健,等.名老中医治疗老年性痴呆经验评述.中医
・研究报告・
糖尿病肾病不同分期证候演变研究
王颖辉1，赵进喜2，王世东2，李景3，庞博3，丁英钧4，李靖2，肖永华2，傅强2，张亚欣2，宫晴3，
周迪夷3，齐铮3，周鑫3，谭倩5，金建宁6，谢莹7，姚帅2，李哲2
（1北京王府中西医结合医院，北京 102209；2北京中医药大学东直门医院，北京 100700；3北京中医药大学， 北京 100029；4河北医科大学中西医结合学院，石家庄 050091；5北京市宣武中医医院，北京 100053；
6
宁夏医科大学总医院，银川 750004；7长春中医药大学附属医院，吉林 130000）
摘要：目的：针对糖尿病肾病（DN）早期、临床期患者，开展糖尿病肾病不同分期证候演变研究。方法：收集早期DN及临床期DN的证候学资料，进行辨证及证素的提炼，对证候及证素进行统计学分析。结果：随着病情由早期演变到临床期，体现阴虚内热，热伤气阴病机的症状逐渐减少，阳虚的症状、证素呈现逐渐增多的趋势，临床期DN湿浊证素较早期DN逐渐增多。结论：DN病机从早期到临床期呈现气阴两虚发展向阴阳两虚的趋势，血瘀等邪实的证候贯穿早期和临床期，并有加重的趋势，其中湿浊证素较早期DN明显增加。
关键词：证候特点；糖尿病肾病；证候演变规律
基金资助：“十一五”国家科技支撑计划资助项目（No.2006BAI04A03-2）
TCM syndrome development research of diabetic nephropathy in different stage
WANG Ying-hui1, ZHAO Jin-xin2, WANG Shi-dong2, LI Jin3, PANG Bo3, DING Ying-jun4,
LI Jin2, XIAO Yong-hua2, FU Qiang2, ZHANG Ya-xin2, GONG Qing3, ZHOU Di-yi3, QI Zheng3,
ZHOU Xin3,TAN Qian5, JIN Jian-ning6, XIE Ying7, YAO Shuai2, LI Zhe2
( 1Beijing Royal Integrative Medicine Hospital, Beijing 102209, China; 2Dongzhimen Hospital Affi liated to Beijing University of Chinese Medicine, Beijing 100700, China; 3Beijing University of Chinese Medicine, Beijing 100029, China; 4School of Integrated Traditional and Western Medicine, Hebei Medical University, Shijiazhuang 050091, China; 5Beijing Xuanwu TCM Hospital, Beijing 100053, China; 6General Hospital of Ningxia Medical University, Yinchuan 750004, China; 7The Affi liated Hospital to
Changchun University of Chinese Medicine, Jilin 130000, China)
通讯作者：赵进喜，北京市东城区海运仓5号北京中医药大学东直门医院内分泌科，邮编：100700，电话：010-84013122E-mail：[email protected]